October 2017

S M T W T F S
12 34 5 67
8 9 1011 12 1314
15 161718192021
22232425262728
293031    

Style Credit

Expand Cut Tags

No cut tags
Tuesday, July 4th, 2017 07:50 am
http://blogs.sciencemag.org/pipeline/archives/2017/07/03/cryptic-natural-products-appearing

When i was listening to the biology & genetic lectures a few years ago, i was astounded by new realizations. The key has to do with how DNA is NOT a blueprint, a description of the final structure. It's much more like computer code, with all the cruft that developers often leave in a great big system, code that used to do something important, but the output is no longer needed. Somehow activate that code path, and the code can still execute. On the other hand, since the system has evolved away from that need, it the code does execute, it's not necessarily going to behave as it did originally.

DNA doesn't execute in a vacuum: chemical and physical signals affect what segments of the DNA will be activated. The embryonic environment has a huge impact on the gene expression in a developing organism -- i can't find a recent article i read about how poverty-stress of a mother can be expressed in the cognitive pathway development of the child, thus providing a physiological basis for poverty changing the way one literally thinks.

(In Butler's Wild Seed, one of the characters could "examine" the DNA of a creature and then express the creature. My awareness of how gene expression works triggered a momentary collapse of my suspension of disbelief.)

So, i pondered, what if an organism was exposed to primordial compounds, compounds that don't exist in the oxygen rich environment of today? What parts of the "junk" DNA might be activated? What might happen next? (Could an alternative being be in the DNA that could be expressed with the right primordial signals?) Keyword for more research: epigenetics.

" It’s for sure that there are many biosynthetic-looking gene clusters found in these species that don’t seem to be turned on most of the time, which makes one think that under the right conditions you could perhaps elicit some “break glass in case of emergency” structures that might be well worth seeing."

Derek Lowe, July 3, 2017


Why, yes, exactly.

[The group] ran all sorts of stress experiments on the organisms to see if any of these caused some activity. As it turns out, exposure to etoposide and to avermectin, both quite toxic to the organisms, caused some of these biosynthetic pathways to turn on, and several new compounds emerged, including one with antifungal activity and some that appear to be cysteine protease inhibitors.


Hint: Wikipedia relates that "Cysteine proteases... are enzymes that degrade proteins."

Organic chemistry and genetics are so incredibly amazing to me. I envy nascent scientists -- so many of these discoveries have been since i was in school. To be entering the fields with this landscape as a foundation....

Reply

From:
Anonymous
OpenID
Identity URL: 
User
Account name:
Password:
If you don't have an account you can create one now.
Subject:
HTML doesn't work in the subject.

Message:

If you are unable to use this captcha for any reason, please contact us by email at support@dreamwidth.org


 
Links will be displayed as unclickable URLs to help prevent spam.